News & Publications

PURPOSE: Merkel cell carcinoma (MCC) is an aggressive skin cancer with neuroendocrine differentiation. There is an unmet need for MCC-specific blood-based surrogate biomarkers of tumor burden; circulating cell-free micro(mi)RNA may serve this purpose. EXPERIMENTAL DESIGN: Expression of miR-375 was q...

The 2018 Annual ASCO meeting was held in Chicago, IL between June 1 - 5th. The Annual Meeting brings together oncology professionals from around the world to discuss state-of-the-art treatment modalities, new therapies, and ongoing controversies in the field. Dr. Paul Nghiem presented on the, "Tw...

On June 13, 2018, Rebecca Voelker, of JAMA Medical News and Perspectives, published an article discussing the rise in interest and incidence of Merkel cell carcinoma. Physicians including Dr. Michael Hori, and Dr. Paul emphasize the importance of receiving appropriate care during diagnostic workup....

Before 2016, patients with advanced Merkel cell carcinoma — a rare and extremely deadly skin cancer — had no good treatment options to extend their lives more than a few months. Then, with two pivotal trials, everything changed. On Monday, investigators presented new, long-term data from these t...

Background: Merkel cell carcinoma (MCC) is a rare but aggressive neuroendocrine skin cancer. The estimated 5-year survival of patients with metastatic disease is approximately 14%. Cytotoxic chemotherapy is associated with a modest median progression-free survival (PFS) of only 3 months. In recent s...

PURPOSE: The causative agent of most cases of Merkel cell carcinoma (MCC) has been identified as the Merkel cell polyomavirus (MCV). MCV encoded T-antigens (Tags) are essential not only for virus-mediated tumorigenesis but also for maintaining MCC cell lines in vitro. MCV Tags are thus an appealing ...

Britain’s National Institute for Health and Care Excellence (NICE) has recommended that the National Health Service cover Bavencio (avelumab) as a treatment for adults with metastatic Merkel cell carcinoma (mMCC), a rare form of skin cancer. The institute’s Final Appraisal Determination (FAD) re...

BACKGROUND: Merkel cell carcinoma (MCC) incidence rates are rising and strongly age-associated, relevant for an aging population. OBJECTIVE: Determine MCC incidence in the United States and project incident cases through the year 2025. METHODS: Registry data were obtained from the SEER-18 Database, ...

MISSISSAUGA, ON, Feb. 22, 2018 /CNW/ - EMD Serono, Canada, the biopharmaceutical business of Merck KGaA, Darmstadt, Germany in the U.S. and Canada, and Pfizer Canada Inc. announced that Health Canada has approved BAVENCIO™ (avelumab for injection) for the treatment of metastatic Merkel cell carcin...

On February 16, 2018, UW Medicine released an article on the projected increase for cases of Merkel cell carcinoma in the United States. This rare, aggressive cancer is rising nearly six times faster than other cancers. Current studies show that the incidence is expected to exceed 3,025 cases by 202...