Testing & Diagnosis / Disease stages

Disease stages

The stage at diagnosis is by far the single most important measure of the chance that the cancer will return.

Overview of Merkel cell carcinoma stages

In 2010, the American Joint Committee on Cancer first adopted a specific system to use for staging MCC. Since 2010 the 7th edition MCC staging system was in use to stage stage Physicians determine the stage of cancer by performing physical exams and tests. Stages describe the extent of cancer within the body, especially whether the disease has spread (metastasized) from the primary site to other parts of the body. Merkel cell carcinoma Merkel cell carcinoma A skin cancer composed of cells that look microscopically similar to normal Merkel cells present in the skin. MCC was first described in 1972 and only in the 1990s was the CK20 antibody developed to make it easily identifiable by pathologists. Many doctors and patients are not aware of this cancer because of its recent description and relative rarity (~2,000 cases/year in the US--roughly 30 times less common than melanoma). About 40% of patients treated for MCC will experience a recurrence, making it far more aggressive than most other types of skin cancer, including melanoma. . This system is the first international “consensus” staging system and it replaced five conflicting systems that were all in use simultaneously. The system was based on an analysis of over 5000 patients using the National Cancer Cancer A term used to describe diseases in which abnormal cells continually divide without normal regulation. Cancerous cells may invade surrounding tissues and may spread to other regions of the body via blood and the lymphatic system. Database as well as an extensive review of the literature. Beginning in 2017, MCC Staging will be carried out using the 8th Edition of the AJCC Staging Manual.

Stages I & II MCC are defined as disease that is localized to the skin at the primary site primary site The area of the body where the abnormal tissue first appeared. . Stage I is for primary lesions less than or equal to 2 centimeters, and stage II is for primary lesions greater than 2 cm. Stage III is defined as disease that involves nearby lymph nodes (regional lymph nodes). Stage IV disease is found beyond regional lymph nodes.

A Closer Look

This staging system, published in the AJCC 7th Edition Manual, was the first to take into account whether an MCC patient’s lymph nodes were tested for spread of the cancer simply by physical exam (clinical staging) or via microscopic/pathologic testing such as by sentinel lymph node biopsy. Although having a node biopsy requires surgery, it results in a much more accurate prediction of whether the cancer will spread or not, and should be considered in most cases.

Determining the stage of Merkel cell carcinoma

MCC is divided into stages depending on the size of the primary tumor and extent of disease in the lymph nodes and elsewhere in the body (metastasis). The stage at diagnosis is the major determinant of the chance for later spread (metastasis) and treatment options.

7th Edition MCC Staging System Table

Stage Primary Tumor Lymph Node Metastasis
0 In situ primary tumor No regional lymph node metastasis No distant metastasis
IA Less than or equal to 2 cm maximum tumor dimension Nodes negative by pathologic exam No distant metastasis
IB Less than or equal to 2 cm maximum tumor dimension Nodes negative by clinical exam* (no pathologic node exam performed) No distant metastasis
IIA Greater than 2 cm tumor dimension Nodes negative by pathologic exam No distant metastasis
IIB Greater than 2 cm tumor dimension Nodes negative by clinical exam* (no pathologic node exam performed) No distant metastasis
IIC Primary tumor invades bone, muscle, fascia, or cartilage No regional lymph node metastasis No distant metastasis
IIIA Any size tumor (includes invading tumors) Micrometastasis** No distant metastasis
IIIB Any size tumor (includes invading tumors) Macrometastasis*** -OR- In transit metastasis**** No distant metastasis
IV Any size tumor (includes invading tumors) Any lymph node metastasis Metastasis beyond regional lymph nodes

* Clinical detection of nodal disease may be via inspection, palpation, and/or imaging.
** Micrometastases are diagnosed after sentinel or elective lymphadenectomy.
*** Macrometastases are defined as clinically detectable nodal metastases confirmed by therapeutic lymphadenectomy or needle biopsy biopsy The removal of cells or tissue in order to determine the presence, characteristics, or extent of a disease by a pathologist usually using microscopic analysis. .
**** In transit metastasis: a tumor distinct from the primary lesion primary lesion The abnormal tissue that appeared first. The majority of Merkel cell carcinoma primary lesions occur in sun-exposed areas. In some cases of MCC (approximately 11%) the patient has no primary lesion and instead has a nodal presentation (disease in a lymph node only). In these cases the primary lesion likely was destroyed by the immune system. and located either (1) between the primary lesion lesion An area of abnormal tissue that may be either benign or malignant. and the draining regional lymph nodes or (2) distal to the primary lesion.
(Adapted from AJCC’s Cancer Staging Manual 2009)

What to do next

The AJCC 7th Edition Staging Manual will be officially replaced by the 8th Edition as of the start of 2017, and information about the 7th system will remain on this site for reference.


How does staging work for MCC?

In general, cancers are staged according to where the cancer is in the body: local (skin only), nodal (involves the lymph nodes), or metastatic (spread elsewhere in the body). The best survival is for local stages; the poorest is in metastatic stages with nodal disease somewhere in between. In the past, there were five different staging systems for MCC, and this created confusion. The AJCC 7th Edition Staging Manual, which is the first international “consensus” staging system, will be officially replaced by the 8th Edition at the start of 2017.

What are the main differences between the 7th & 8th Editions of the AJCC Staging Systems for MCC?

It has recently been realized that MCC patients with nodal disease who have no known primary lesion do better than node-positive patients who still have a primary lesion in place.  These two categories of Stage III (nodal) disease are separated in the new system, resulting in more accurate prediction of recurrence. In the 8th Edition system, it is now necessary to note whether staging was ‘clinical’ or ‘pathologic’ (see table in 8th Edition system) for a summary.

Understand the Science

The following clinical publications and scientific research provide additional in-depth information about disease stages.

AJCC Cancer Staging Manual

On January 1, 2010, the American Joint Committee on Cancer (AJCC) adopted a new staging system for MCC. Dr. Nghiem led the MCC taskforce of the AJCC in this analysis and wrote the chapter with Dr. Bianca Lemos. The chapter is available here for download or accessible online via the link below.

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Pathologic nodal evaluation improves prognostic accuracy in Merkel cell carcinoma: analysis of 5823 cases as the basis of the first consensus staging system.

The data and analysis to create a new staging system for Merkel cell carcinoma, now used worldwide, was published in the Journal of the American Academy of Dermatology. This was based on survival data from over 5000 MCC patients and reinforced the importance of sentinel lymph node biopsy in prognosi...

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