American Academy of Dermatology Annual Meeting
San Francisco, CA
Prepared by Drs. Jayasri Iyer & Paul Nghiem
Goals of MMIG
MMIG is funded in part by a grant from the Jerry Wachter Fund of the American Cancer Society (www.jw.org).
Please note that in some cases these summaries reflect unpublished data and are provided to help MMIG members manage their patients and give an overview of what is being done at different centers for care and research.
Dr. Nghiem presented a late stage proposed unified staging system that will likely be adopted by both the AJCC and the UICC worldwide. Publication is anticipated in late 2009 for adoption on Jan 1, 2010. It is not appropriate to officially use this system until publication because it is not yet final and there is no appropriate citation at this point. The major changes from existing systems are inclusion of sub-stages for method of nodal evaluation (clinical evaluation vs. pathologic evaluation) and for clinically apparent vs only microscopic nodal involvement. Also, 2.0 cm tumors are now included in Stage I rather than Stage II (this is consistent with the prior AJCC system but differs from other common systems). The outline of the proposed staging system is as follows:
Stage I: Local, ≤ 2cm
Ia: Nodes microscopically negative and not clinically detectable
Ib: Nodes not clinically detectable (no pathologic eval of nodes done)
Stage II: Local, > 2cm
IIa: Nodes microscopically negative and not clinically detectable
IIb: Nodes not clinically detectable (no pathologic eval of nodes done)
IIc: Primary tumor invading bone/muscle/fascia/cartilage
Stage III: Regional Nodal Disease
IIIb: Macrometastasis (clinically detectable)
Stage IV: Distant Metastatic Disease
Together with Dr. David Frishberg, a new, specific set of required pathologic features will be published online in the next few months. The Checklist will be available via the CAP website (http://www.cap.org/apps/cap.portal). Major pathology centers will follow these guidelines that will standardize required and optional features that should be included in pathology reports for MCC. The Checklist has been coordinated with the new AJCC/UICC staging system and also with the pathologic features that will be collected by tumor registrars when recording MCC cases for future studies.
Based on suggestions from other MMIG group members, Drs. Iyer & Nghiem led an effort in 2008-09 in which we petitioned the CDC and appropriate World Health Organization entities to create ICD-9 codes that are specific for MCC. Currently, MCC is coded with malignant neoplasms of skin (173.x) which includes BCC and dozens of other skin cancers. This petition was reviewed in a variety of steps in 2008 and then at a formal meeting in January 2009 in Maryland where it was accepted. We were particularly pleased that they granted EIGHT CODES specific to MCC as summarized below. These codes are similar in nature to those for melanoma. Beginning in October 2009, MCC should be reported using these new codes that will go into the use around the world. This will greatly improve our ability to obtain insurance approval for procedures for MCC patients, as well as track costs, incidence, etc for this cancer.
Dr Bichakjian summarized the major changes in the National Comprehensive Cancer Network (NCCN) guidelines for 2009 for MCC. These changes mostly focused on radiation and chemotherapy. The guidelines are annually update, multi-disciplinary, reflective of practice across the major cancer centers in the US and can be found at: http://www.nccn.org/professionals/physician_gls/PDF/mcc.pdf
Dr. Marsden has proposed a randomized trial for MCC that would be a feasibility trial to start in the UK. A final decision on availability of funding (nearly $1M) will be determined in a few months. If it is funded, it will randomize patients with local or nodal MCC to receive standard therapy alone or standard therapy plus cisplatin/etoposide.
Dr. Yu led a spirited discussion about complex cases of MCC she has managed. Several of the relevant points from these cases are listed in the discussion points below. In particular, her presentation led to discussions on the WIDE variation in practice habits across institutions in obtaining scans and use of radiation.Download PDF
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