Treatment / Surgical excision

Surgical excision

A treatment option to remove the cancer from the primary site and from the lymph nodes that are nearby.

Purpose of surgical excision

The goal of surgical excision excision The removal of tissue of interest by surgery. for Merkel cell carcinoma Merkel cell carcinoma A skin cancer composed of cells that look microscopically similar to normal Merkel cells present in the skin. MCC was first described in 1972 and only in the 1990s was the CK20 antibody developed to make it easily identifiable by pathologists. Many doctors and patients are not aware of this cancer because of its recent description and relative rarity (~2,000 cases/year in the US--roughly 30 times less common than melanoma). About 40% of patients treated for MCC will experience a recurrence, making it far more aggressive than most other types of skin cancer, including melanoma. is to remove the Merkel cell Merkel cell Merkel cells are found in the lower part of the epidermis. Although the exact function of Merkel cells is unknown, they are thought to be touch receptors. Also known as neuroendocrine cells, they have machinery similar to nerve cells and to hormone-secreting (endocrine) cells. carcinoma carcinoma Cancer that originates in the skin or in the tissues lining the gut and ducts. so that it does not recur near the primary site primary site The area of the body where the abnormal tissue first appeared. or in the nearby lymph nodes. The primary MCC tumor should ideally be removed with clear margins (no microscopic tumor at edge of excision) as judged by pathology examination. As noted below however, even with margins >2 cm, surgery alone can have a high recurrence rate near the primary MCC site of up to 42%, depending on the study. The chance of local local Affecting only the site of origin, without evidence of spreading. Compare to systemic. recurrence after surgical excision of the primary tumor is far higher for MCC than for the more common types of skin cancer cancer A term used to describe diseases in which abnormal cells continually divide without normal regulation. Cancerous cells may invade surrounding tissues and may spread to other regions of the body via blood and the lymphatic system. ( basal cell carcinoma basal cell carcinoma Skin cancer that arises from basal cells, a cell type found in the innermost layer of the epidermis. Compared to other skin cancers, basal cell carcinoma is rarely lethal. Less than 1 in 50,000 patients with basal cell carcinoma will die from this disease. , squamous cell carcinoma squamous cell carcinoma Squamous cell carcinoma is a cancer that begins in squamous cells, which are thin, flat cells. Squamous cells are located in the middle layers of the epidermis, the lining of portions of the respiratory and digestive tracts, and the lining of some organs. Squamous cell carcinoma affects about 100,000 Americans and has a mortality of roughly 2%. or even melanoma melanoma A form of skin cancer that begins in melanocytes (the skin cells that produce the pigment melanin). Melanoma affects about 42,000 Americans per year and has about a 15% mortality. ) because MCC more often “jumps” discontinuously to adjacent normal-appearing skin, with recurrences happening quite commonly up to several centimeters away from the edge of the primary tumor. The local recurrence rate can be as high as 20-40% depending on the study, and can typically be cut to less than 5% by the addition of radiation therapy radiation therapy The use of radiation to kill cancer cells and shrink tumors. Merkel cell carcinoma is a highly radiation sensitive cancer in most cases. . Importantly, if radiation will be used at the primary site, it is not required for the surgeon to obtain clear margins because radiation kills isolated tumor cells in the radiation field which usually extends at least 5 cm beyond where the tumor was. See the Radiation therapy page for guidelines about how to decide whether or not radiation should be used for a given patient.

Surgical excision for Merkel cell carcinoma
Schematic of wide surgical excision: An excision taken with wide margins, generally approximately 1 cm or greater in an attempt to surgically remove a cancer. with MCC shown in gray.

To optimize the appearance and function of the scar, the surgeon may make an excision in the shape of a football (ellipse). The length of the scar will be roughly three times the diameter of the excision around the tumor. (When possible, the excision is usually 2 cm beyond the tumor). Therefore, the scar may be up to eight times as long as the width of the original MCC tumor.

A Closer Look

In relatively low risk MCC tumors, surgery alone can be sufficient, as has been well documented especially by the groups at Memorial Sloan Kettering Cancer Center and University of Michigan.3 4 Among a large series of cases from the literature, the addition of adjuvant radiation to surgery decreased the risk of local recurrence by several fold.

Who this works for

Most patients will benefit from at least a narrow excision of their primary tumor that removes all of the tumor that can be readily felt or seen.

Who this doesn’t work for

Depending on your general health and the location and size of the MCC, surgery may not be possible. In such cases, radiation therapy is sometimes used alone. Several studies suggest that radiation therapy alone may be nearly as effective as both radiation therapy and surgery.1 2

Side effects

Surgical excision side effects are highly dependent on the location and size of the tumor and they mostly relate to how much skin needs to be excised near the tumor.

Often used in conjunction with

Radiation therapy of the area that was excised is often given to lower the risk of recurrence at the surgical site.

What to do next

After surgery is done, the pathology results should be reviewed by your team to determine whether or not radiation should be added. If not already performed, a baseline scan may be indicated. As soon as possible, an oncoprotein antibody titer antibody titer An antibody titer reflects the amount of a particular antibody in the blood. should be checked.


What is the correct surgical margin size for a Merkel cell carcinoma?

This is an extremely tricky and controversial point. If radiation will be used, then surgical margins can be very small and narrow (just taking out the obvious portion of the tumor provides superb results when combined with adjuvant radiation). In contrast, if radiation is not planned, margins that are greater than 1 cm (ideally 2 cm) are associated with a lower risk of recurrence.

When is surgery alone sufficient for treating Merkel cell carcinoma (no radiation)?

This is an extremely controversial area. Some studies, including ones by Bichakjian and Coit, suggest that MCCs can be treated with surgery alone, with very few patients experiencing relapse. Other studies suggest that radiation cuts the risk of local recurrence by 2-3 fold. A reasonable approach is that surgical excision alone is likely sufficient for certain low-risk tumors. For example, no radiation is usually needed if the tumor is relatively small (<2cm), the sentinel lymph node biopsy is negative, larger surgical excision margins are achieved (typically about 2cm), there is no lymphovascular invasion noted by the pathologist, if the pathologist cannot find any tumor cells at the margin, and if the patient is not immune suppressed. If these higher risk factors are present, it means there would likely be greater benefit of adding radiation therapy.

When should the sentinel lymph node biopsy performed?

It is important to perform a sentinel lymph node biopsy at the time of (or prior to) a significant re-excision surgery.  This is because extensive surgery at the site of the tumor disrupts the tiny lymphatic vessels that connect the tumor to the regional 1-2 lymph nodes where the cancer may have spread microscopically.

Do I need surgery?

A surgical excision is usually performed after a diagnostic biopsy as the first step of appropriate treatment for MCC. The goal of surgery is to remove any remaining cancer that can be seen either by the naked eye or under a microscope.

Understand the Science

The following clinical publications and scientific research provide additional in-depth information about surgical excision.

Recurrence after complete resection and selective use of adjuvant therapy for stage I through III Merkel cell carcinoma.

Merkel cell carcinoma (MCC) is a rare cutaneous neuroendocrine neoplasm whose natural history is poorly understood. Here, the authors describe their experience with a large cohort of patients who were treated at a single institution to describe patterns of recurrence after curative therapy.

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Adjuvant local irradiation for Merkel cell carcinoma.

The June 2006 issue of the Archives of Dermatology features several articles on Merkel cell carcinoma discussing the role of sentinal lymph node biopsy in prognosis and improved therapy, the importance of adjuvant radiation and an editorial highlighting the management and treatment of MCC. This stud...

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Recurrence and Survival in Patients With Merkel Cell Carcinoma Undergoing Surgery Without Adjuvant Radiation Therapy to the Primary Site.

The use of adjuvant radiation therapy (RT) to the primary site in Merkel cell carcinoma (MCC) is not uncommon. However, the need for adjuvant RT to the primary site in patients at low risk for local recurrence is questionable. Objectives: To examine the occurrence of true local, satellite, in-transi...

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Radiotherapy alone for Merkel cell carcinoma: a comparative and retrospective study of 25 patients.

Merkel cell carcinoma (MCC) is a rare skin cancer. Cumulative data from retrospective series support the notion that benefits are obtained by both wide excision and adjuvant radiation therapy. However, surgery may be difficult to perform with tumors located in the head and neck region and/or in elde...

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Radiotherapy alone in patients with Merkel cell carcinoma: the Westmead Hospital experience of 41 patients.

Objectives: To review the role of radiotherapy as treatment (RTx) alone in patients with Merkel cell carcinoma (MCC). Methods: Data on 41 patients with MCC treated with RTx alone between 1993 and 2013 at Westmead Hospital, Sydney, were reviewed and analysed. Results: The patients' median age was 80 ...

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