Journal of Investigative Dermatology
September 1, 2007
Lemos B, Nghiem PDownload PDF
Drs. Nghiem and Lemos published a short review of the biology of Merkel cell carcinoma in the Journal of Investigative Dermatology.
Merkel cell carcinoma (MCC) is a neuroendocrine skin cancer with a rising incidence (1500 U.S. cases per year) that now exceeds that of cutaneous T-cell lymphoma and a mortality (33%) exceeding that of melanoma. Despite this impact, little is known about its biology. Recent studies have shown that Ras/MAP kinase activity is absent and possibly detrimental to this cancer. This makes MCC distinct from other UV–induced skin cancers and highlights the question of what drives this malignancy.
The authoritative source on Merkel cell carcinoma.
April 20, 2019