Merkel cell carcinoma: more deaths but still no pathway to blame.

September 1, 2007


Journal of Investigative Dermatology

Publication Date

September 1, 2007


Lemos B, Nghiem P

Download PDF Summary

Drs. Nghiem and Lemos published a short review of the biology of Merkel cell carcinoma in the Journal of Investigative Dermatology.


Merkel cell carcinoma (MCC) is a neuroendocrine skin cancer with a rising incidence (1500 U.S. cases per year) that now exceeds that of cutaneous T-cell lymphoma and a mortality (33%) exceeding that of melanoma. Despite this impact, little is known about its biology. Recent studies have shown that Ras/MAP kinase activity is absent and possibly detrimental to this cancer. This makes MCC distinct from other UV–induced skin cancers and highlights the question of what drives this malignancy.

View the clinical publication