How we treat Merkel cell carcinoma: within and beyond current guidelines

April 1, 2021

Journal

Future Oncology

Publication Date

April 1, 2021

Author

Song Y Park, Coley Doolittle-Amieva, Yasman Moshiri, Tomoko Akaike, Upendra Parvathaneni, Shailender Bhatia, Lisa C Zaba, and Paul Nghiem

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Abstract

Merkel cell carcinoma (MCC) is a skin cancerwith a high risk of recurrence and distant spread. Optimal care of this cancer is important. However, management is challenging because it is rare and its treatment is continuously evolving across multiple specialties. While treatment guidelines offer a broad overview of management, they are often not detailed enough to provide appropriate patient-specific assistance. Herein, we present a review of recent studies and our suggestions relevant to MCC staging, surveillance and treatment options. Each of these areas are discussed in light of how they can be appropriately customized for challenging situations often encountered by practitioners. We also provide representative examples of MCC patient scenarios and how they were managed by a multidisciplinary team to identify evidence-based, individualized treatment plans.

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